Gene Expression Profile Reveals Abnormalities of Multiple Signaling Pathways in Mesenchymal Stem Cell Derived from Patients with Systemic Lupus Erythematosus

Table 2

Differentially expressed genes in regulation of actin cytoskeleton and TGF-β signaling between SLE patients and normal controls.

Upregulated genes in actin cytoskeleton pathway	Fold	𝑃 value
ACTN4	2.30	≤1.0𝐸−6
ACTB	2.41	≤1.0𝐸−6
VAV1	4.08	≤1.0𝐸−6
MATK	2.85	≤1.0𝐸−6
ITGB5	8.46	≤1.0𝐸−6
ITGB4	2.43	≤1.0𝐸−6
Downregulated genes in actin cytoskeleton pathway
KRAS	5.62	≤1.0𝐸−6
ARPC3	2.17	≤1.0𝐸−6
ARPC4	2.10	≤1.0𝐸−6
ARPC5	2.53	≤1.0𝐸−6
NRAS	2.01	≤1.0𝐸−6
GNG12	2.17	≤1.0𝐸−6
NCKAP1	3.16	≤1.0𝐸−6
ITGA1	3.63	≤1.0𝐸−6
CRKL	2.71	≤1.0𝐸−6
ITGB5	2.58	≤1.0𝐸−6
PPP1CC	3.36	≤1.0𝐸−6
CFL2	2.06	≤1.0𝐸−6
ROCK2	2.38	≤1.0𝐸−6
PDGFRA	2.77	≤1.0𝐸−6
F2R	2.57	≤1.0𝐸−6
RDX	2.23	≤1.0𝐸−6
PPP1R12A	2.99	≤1.0𝐸−6
ARHGEF6	2.31	≤1.0𝐸−6
ITGAV	7.84	≤1.0𝐸−6
CRK	2.71	≤1.0𝐸−6
Upregulated genes TGF-β signaling
BMP5	4.23	≤1.0𝐸−6
Downregulated genes TGF-β signaling
SMAD1	2.08	≤1.0𝐸−6
SMAD5	2.60	≤1.0𝐸−6
SMURF2	2.66	≤1.0𝐸−6
ID1	3.81	≤1.0𝐸−6
BMPR1A	3.03	≤1.0𝐸−6
TGFBR1	4.50	≤1.0𝐸−6
TGFBR2	2.01	≤1.0𝐸−6
ACVR1	3.12	≤1.0𝐸−6
CREBBP	2.06	≤1.0𝐸−6
ROCK2	2.38	≤1.0𝐸−6
RPS6KB1	2.64	≤1.0𝐸−6
CDKN2B	2.03	≤1.0𝐸−6
THBS1	3.14	≤1.0𝐸−6
THBS3	2.11	≤1.0𝐸−6
THBS2	3.05	≤1.0𝐸−6
LTBP1	2.27	≤1.0𝐸−6
COMP	4.89	≤1.0𝐸−6
FST	2.23	≤1.0𝐸−6