The Association between Polymorphisms of Vitamin D Metabolic-Related Genes and Vitamin D3 Supplementation in Type 2 Diabetic Patients
Table 2
25(OH)D level and insufficiency risk in patients with different SNP genotypes after vitamin D3 supplementation.
Gen
SNP
Gene locus
ng/mL, (%)
ng/mL, (%)
RR (95% CI)a
b
RR (95% CI)c
d
CYP2R1
rs10766197
G/G
30 (60)
20 (40)
1
0.666
1
0.693
A/A
8 (50)
8 (50)
1.25 (0.63, 2.18)
1.19 (0.60, 2.10)
A/G
24 (52.17)
22 (47.83)
1.19 (0.76, 1.91)
1.202 (0.76, 1.92)
rs10741657
G/G
22 (48.89)
23 (51.11)
1
0.244
1
0.294
A/A
11 (73.33)
4 (26.67)
0.52 (0.17, 1.10)
0.54 (0.18, 1.15)
A/G
29 (55.77)
23 (44.23)
0.87 (0.56, 1.33)
0.87 (0.56, 1.32)
CYP27B1
rs10877012
T/T
26 (48.15)
28 (51.85)
1
0.031
1
0.046
G/G
8 (42.11)
11 (57.89)
1.12 (0.66, 1.71)
1.15 (0.67, 1.81)
G/T
28 (71.79)
11 (28.21)
0.54 (0.29, 0.92)
0.56 (0.29, 0.98)
rs4646536
C/C
26 (48.15)
28 (51.85)
1
0.031
1
0.046
T/T
8 (42.11)
11 (57.89)
1.12 (0.66, 1.71)
1.15 (0.67, 1.81)
C/T
28 (71.79)
11 (28.21)
0.54 (0.29, 0.92)
0.56 (0.29, 0.98)
CYP24A1
rs6013897
T/T
43 (57.33)
32 (42.67)
1
0.209
1
0.212
A/A
2 (100)
0 (0)
—
—
A/T
17 (48.57)
18 (51.43)
—
—
DHCR7
rs12785878
T/T
18 (60)
12 (40)
1
0.082
1
0.110
G/G
23 (67.65)
11 (32.35)
0.81 (0.41, 1.58)
0.82 (0.41, 1.60)
G/T
21 (43.75)
27 (56.25)
1.41 (0.88, 2.47)
1.39 (0.87, 2.45)
VDR
rs2228570
T/T
14 (53.85)
12 (46.15)
1
0.964
1
0.943
C/T
11 (57.89)
8 (42.11)
0.97 (0.61, 1.68)
1.02 (0.64, 1.76)
C/C
37 (55.22)
30 (44.78)
0.91 (0.435, 1.77)
0.92 (0.44, 1.78)
rs1544410
G/G
5 (71.43)
2 (28.57)
1
0.367
1
0.404
A/G
57 (54.29)
48 (45.71)
0.63 (0.12, 1.48)
0.66 (0.12, 1.52)
Note: RR of ng/mL. aUncorrected RR. cCorrects age and amount of outdoor activity. value is ng/mL versus ≥30 ng/mL in comparison of all SNP genotypes. bUncorrected RR. dCorrects age and amount of outdoor activity. Bold values are .
