Large Gliadin Peptides Detected in the Pancreas of NOD and Healthy Mice following Oral Administration

Figure 1

Quantification of ³H-33-mer, ³H-19-mer, and ³H-tyrosine following oral ingestion in NOD mice in intestine (white), pancreas (red), and other tissues (green). (a) Radioactivity relative to blood in selected tissues 1, 24, and 72 h after oral administration of ³H-33-mer to mice aged 8 and 12 weeks, of ³H-19-mer to mice aged 12 weeks, and of ³H tyrosine to mice aged 20 weeks (–4 mice). Error bars represent SEM. Sto (stomach), Duo (duodenum), Jej (jejunum), Ile (ileum), Pan (pancreas), Liv (liver), Gal (gallbladder), Spl (spleen), Kid (kidney), Hea (heart), Lun (lung), and Thy (thyroid gland). (b) Tissue distribution of ³H-33-mer, ³H-19-mer, and ³H-tyrosine tracer in NOD mice 0.5, 1, and 3 hours after oral administration. NOD mice (6–8 weeks) were given ³H-33-mer (upper), ³H-19-mer (middle), or ³H-labeled tyrosine (bottom). mice. Error bars represent SEM. The abbreviations are as above.

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