Angioblast Derived from ES Cells Construct Blood Vessels and Ameliorate Diabetic Polyneuropathy in Mice

Figure 9

Transplantation of angioblast-like cells induced from ES cells (ES-ABs) improved delayed nerve conduction velocities (NCVs) in diabetic mice. Motor nerve conduction velocity (MNCV) (a) and sensory nerve conduction velocity (SNCV) (b) of diabetic mice were significantly delayed compared with those of normal mice after 12 weeks duration of diabetes. The delays in MNCV and SNCV were significantly restored by ES-ABs transplantation. However, administrations of ES-ABs did not alter NCVs in normal mice. N: normal mice limbs, DM: diabetic mice limbs, S: saline-injected limbs, AB+: limbs transplanted ES-ABs, and AB−: contralateral limbs transplanted ES-ABs. Results are means ± SD. versus pretreatment N, versus posttreatment S-treated N, and versus posttreatment S-treated DM. in each pretreatment group and –10 in each posttreatment group.

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