Fenofibrate Treatment Enhances Antioxidant Status and Attenuates Endothelial Dysfunction in Streptozotocin-Induced Diabetic Rats
Figure 3
Contractile responses to NG-Nitro-L-arginine methyl ester (L-NAME) (100 μM) in the endothelium-intact rings of control (C), and diabetic (D) rats treated with/without fenofibrate (FF). Responses were evaluated by calculating the ratio of additional contractions induced by L-NAME to the precontraction elicited by phenylephrine given at median effective concentration (EC50). The contractile responses obtained by L-NAME indicate the production of nitric oxide as a product of basal endothelial NO synthase activity. Values are mean ± SEM of data obtained from 10 rats in each group. * versus C; # versus D.
