Lipoplatin Formulation Review Article

Table 1

Pharmacokinetic parameters of total platinum in patients’ sera at the different dose levels.

Dose	Pts	AUC0∅A	𝐶max	Cl	𝐾el	𝑡1/2	𝑉𝑠𝑠
mg/m^2	(n)	(h μg/mL)	(μg/mL)	(L/m^2 h)	(L/h)	(h)	(L/m^2)
25	5	139.63	2.48 ± 1.18	0.18	0.0114	60.79	15.71
50	3	119.19	2.87 ± 0.59	0.42	0.0001	N/A	N/A
100	5	172.89	3.74 ± 1.18	0.58	0.0059	117.46	98.03
125	4	256.09	5.65 ± 2.67	0.49	0.0085	81.53	57.42

N/A, not applicable.