Targeted Liposomal Drug Delivery to Monocytes and Macrophages

Table 1

Examples of therapeutic applications using monocyte/macrophage-targeted liposomes.

Ligand	Active	Disease	Reference
Anionic lipids
	Dexamethasone	Atherosclerosis	[22]
	SLPI	Inflammatory lung disease	[23]
	Bisphosphonates	Restnosis	[24]
	Rifampicin	Tuberculosis	[25]
	Dideoxycytidine-5^′-triphosphate	HIV	[26]
	Clarithromycin	Mycobacterium avium infection	[27]
Peptides
Muramyl tripeptide (MTP)	MTP-phosphotidylethanolamine	Osteosarcoma	[28]
Arg-Gly-Asp (RGD)	Diclofenac sodium (model drug)	Cerebrovascular disease	[29]
Antibodies
Anti-VCAM-1	Prostaglandins	Atherosclerosis	[30]
Anti-CC52	—	Colon Cancer	[31]
Anti-CC531	—	Colon Adenocarcinoma	[32]
Anti-CD11c/DEC-205	tumour antigen (OVA)	Cancer	[21]
Lectins
Mann-C4-Chol	Dexamethasone palmitate	Inflammatory lung disease	[33]
Man2DOG	—	—	[34]
Aminophenyl-𝛼-D-mannopyranoside	Doxorubicin	Experimental visceral leishmaniasis	[6]
	Ciprofloxacin	Respiratory infection	[5]
Man3-DPPE	OVA		[35]
	—	Gastric cancer	[36]
Other Ligands
Maleylated bovine serum albumin (MBSA)			[25]
O-steroly amylopectin (O-SAP)			[25]
Fibronectin			[37]
Galactosyl			[37]