The Use of Radioactive Marker as a Tool to Evaluate the Drug Release in Plasma and Particle Biodistribution of Block Copolymer Nanoparticles
Figure 4
Plasma 3[H] profile of 3[H] CHE-labelled Propac 7/POPC/PS prepared at different polymer ratios. 3[H] CHE-labelled nanoparticles were prepared with 4 different ratios of Propac 7 and PS. Data for 3[H] levels is plotted. Each data point represents the mean (± standard deviation) of three mice. Clearance of Propac 7/POPC/PS 1 : 1 : 1 and 2 : 2 : 1 nanoparticles is significantly faster than 4 : 1 : 1 nanoparticles ( at each time points).
