Review Article
The Trojan Horse Liposome Technology for Nonviral Gene Transfer across the Blood-Brain Barrier
Table 3
Tyrosine hydroxylase (TH) in brain and apomorphine-induced contralateral rotation after intravenous injection of gene therapy with TH expression plasmids.
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Rx: single IV injection of TfRMAb-targeted THLs encapsulating the respective TH expression plasmid. *Mean ± S.E. (–6 rats per point). Statistically significant differences were determined by Student’s t-test. Clone 877 is the TH expression plasmid driven by the SV40 promoter. For details in the engineering of TH genomic vectors, clones prgTH2–TH4, please see Figure 5. Difference with saline: a; b. Difference with clone 877: c; d. NA: not applicable. From [48]. |