Synthesis, Molecular Docking Studies, and Antifungal Activity Evaluation of New Benzimidazole-Triazoles as Potential Lanosterol 14α-Demethylase Inhibitors

Figure 4

(a) The two-dimensional interacting mode of compound 5s in the active region of lanosterol 14-α-demethylase. (b) The three-dimensional interacting mode of compound 5s in the active region of lanosterol 14-α-demethylase. The inhibitor is colored with maroon. The HEM molecule is colored green with ball-and-stick model. The binding energy of 5s is −85.218 kcal/mol.

(a)

(b)