Fluconazole-Pyridoxine Bis-Triazolium Compounds with Potent Activity against Pathogenic Bacteria and Fungi Including Their Biofilm-Embedded Forms

Table 2

In vitro antibacterial activity of the obtained compounds 4a,b and the reference drugs (MICs, μg/mL)

Compounds	Gram (+)				Gram (−)
	S. aureus АТСС 29213	B. subtilis 168	S. epidermidis	M. luteus	E. coli АТСС 25922	K. pneumoniae	P. aeruginosa АТСС 27853	S. typhimurium TA100
4a	>64	32	32	n.m.	>64	>64	>64	n.m.
4b	0.5	2	8	4	16	32	32	8
4b + CaCl2	>64	>64	>64	n.m.	>64	>64	>64	n.m.
Fluconazole	>64	>64	>64	n.m.	>64	>64	>64	n.m.
Terbinafine	>64	>64	>64	n.m.	>64	>64	>64	n.m.
Benzalkonium chloride	4	2	8	4	16	>64	32	8
Miramistin	2	1	4	4	8	n.m.	64	4

.m., not measured.