Fluconazole-Pyridoxine Bis-Triazolium Compounds with Potent Activity against Pathogenic Bacteria and Fungi Including Their Biofilm-Embedded Forms

Table 1

Activity of compounds 4a,b on a panel of fungal pathogens.

Compound	Strains	MIC, μg/mL
		400	200	100	50	25	12.5	6.25	3.12	1.5	0.75	0.38
Fluconazole	C. albicans	0	0	0	0	1	1	3	4	4	4	4
	T. rubrum	2	4	4	4	4	4	4	4	4	4	4
	A. fumigatus	3	4	4	4	4	4	4	4	4	4	4
	R. nigricans	4	4	4	4	4	4	4	4	4	4	4
Terbinafine	C. albicans	0	0	0	0	0	0	0	0	0	0	1
	T. rubrum	0	0	0	0	0	0	0	0	1	1	2
	A. fumigatus	0	0	0	0	0	0	1	1	3	4	4
	R. nigricans	0	0	0	0	0	0	0	1	1	4	4
4a	C. albicans	0	0	0	0	0	2	2	3	4	4	4
	T. rubrum	0	0	4	4	4	4	4	4	4	4	4
	A. fumigatus	0	0	4	4	4	4	4	4	4	4	4
	R. nigricans	0	0	4	4	4	4	4	4	4	4	4
4b	C. albicans	0	0	0	0	0	0	0	0	0	4	4
	T. rubrum	0	0	0	0	0	0	0	1	4	4	4
	A. fumigatus	0	0	0	0	0	0	0	0	1	4	4
	R. nigricans	0	0	0	0	0	0	0	0	1	2	4

Note. 0 = clear solution, no growth; 1 = weak growth (25% of control); 2 = significant inhibition of growth (50% of control); 3 = insignificant growth inhibition (75% of control); 4 = no growth inhibition (100% of control).