Research Article
Fluconazole-Pyridoxine Bis-Triazolium Compounds with Potent Activity against Pathogenic Bacteria and Fungi Including Their Biofilm-Embedded Forms
Table 1
Activity of compounds 4a,b on a panel of fungal pathogens.
| Compound | Strains | MIC, μg/mL | 400 | 200 | 100 | 50 | 25 | 12.5 | 6.25 | 3.12 | 1.5 | 0.75 | 0.38 |
| Fluconazole | C. albicans | 0 | 0 | 0 | 0 | 1 | 1 | 3 | 4 | 4 | 4 | 4 | T. rubrum | 2 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | A. fumigatus | 3 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | R. nigricans | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 |
| Terbinafine | C. albicans | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | T. rubrum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 2 | A. fumigatus | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3 | 4 | 4 | R. nigricans | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4 | 4 |
| 4a | C. albicans | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 3 | 4 | 4 | 4 | T. rubrum | 0 | 0 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | A. fumigatus | 0 | 0 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | R. nigricans | 0 | 0 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 |
| 4b | C. albicans | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 4 | T. rubrum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 4 | 4 | A. fumigatus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 4 | R. nigricans | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 4 |
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Note. 0 = clear solution, no growth; 1 = weak growth (25% of control); 2 = significant inhibition of growth (50% of control); 3 = insignificant growth inhibition (75% of control); 4 = no growth inhibition (100% of control).
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