Acetylcholinesterase and Butyrylcholinesterase Inhibitory Activities of β-Carboline and Quinoline Alkaloids Derivatives from the Plants of Genus Peganum

Table 1

Inhibitory activity (IC₅₀) and selectivity index (SI) of the compounds investigated against AChE and BChE.

Compounds	IC50 (𝜇M ± SD)		SI
	AChE	BChE
Galanthamine	1.18 ± 1.05	/
	0.8 [21]	7.3 [21]	9.13
Harmane	7.11 ± 2.00	76.91 ± 1.57	10.82
Harmine	9.05 ± 1.08	75.07 ± 1.29	8.30
Harmaline	10.58 ± 2.01	101.39 ± 1.39	9.58
Harmol	21.58 ± 1.39	8.21 ± 3.65	0.38
Harmalol	27.88 ± 1.13	9.48 ± 2.03	0.34
Vasicine	13.68 ± 1.25	2.60 ± 1.47	0.19
Nigellastrine II	40.46 ± 1.09	9.26 ± 1.47	0.23
Nigellastrine I	70.50 ± 1.14	18.24 ± 3.23	0.26
Vasicinone	370.78 ± 1.07	—
Deoxyvasicinone	294.44 ± 1.47	—
Deoxyvasicine	—	—
1,2,3,4-tetrahydroharmane-3-carboxylic acid	—	—

IC₅₀ values were determined by regression analyses and expressed as the means ± SD of three replicate determinations. SI is the AChE selectivity index defined as IC₅₀ BChE/IC₅₀ AChE affinity ratio.
—: no inhibitory activity.