Could Microparticles Be the Universal Quality Indicator for Platelet Viability and Function?
Table 1
Comparison of microparticle testing technologies.
Technology
Principle
Manufacturer
Invasive1
Standards, dilutions required
Trained specialist required
MP separation required
Prep. time [min]
Time/test [min]
Daily maintenance
ThromboLUX
DLS
LightIntegra
No
No
No
No
5
8
No
Flow cytometer
Static light scattering, fluorescence
Abbott, Becton Dickinson amongst others
No
Yes
Yes
Yes
30+
5–10
Yes
Micro flow cytometer
Static light scattering, fluorescence
Apogee flow systems
No
Yes
Yes
Yes
30+
Yes
qNano Gold
Size exclusion chromatography
Izon Science
Yes
Yes
Yes
Yes
10–15
No
NanoSight
DLS particle tracking
Malvern
Yes
Yes
Yes
Yes
15
6–75
No
ELISA
Double antibody sandwich technique
JIMRO Co. Ltd., Diagnostica Stago
No
Yes
Yes
Yes
30+
5–10
No
test is considered invasive if the required sample volume is larger than what can be aseptically obtained from a tubing segment. only usable for 6–8 hours. of microparticles by differential centrifugation or size exclusion chromatography required, dynamic light scattering (DLS), microparticles (MP), and enzyme-linked immunosorbent assay (ELISA).
