A Coupled Phase-Temperature Model for Dynamics of Transient Neuronal Signal in Mammals Cold Receptor

<div>The burst phenomenon (top panel) and <svg height="12.235pt" id="M137" style="vertical-align:-3.27288pt" version="1.1" viewbox="-0.0498162 -8.96212 16.8069 12.235" width="16.8069pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M620 675H597C578 656 570 650 541 650H144C112 650 104 653 94 675H72C59 618 42 552 23 493L53 491C71 534 88 564 105 585C124 608 144 615 238 615H290L197 121C182 40 174 34 88 28L82 0H361L367 28C275 34 266 38 281 121L374 615H441C522 615 543 608 553 583C562 560 566 531 565 493L597 494C603 551 612 629 620 675Z" id="g113-85"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="637" vert-adv-y="637"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,7.176,3.132)"><path d="M380 106C343 72 306 56 265 56C195 56 116 112 115 248C235 252 361 262 377 265C396 269 400 277 400 297C400 374 333 449 250 449H249C198 449 144 421 103 376S37 269 37 201C37 88 109 -12 232 -12C263 -12 332 6 395 84L380 106ZM225 412C281 412 315 364 314 312C314 297 308 292 290 292C232 290 176 289 120 289C135 370 180 412 225 412Z" id="g190-102"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="425" vert-adv-y="425"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,11.044,3.132)"><path d="M99 437H52L25 408L28 397H99V104C99 38 91 32 32 26V0H246V25C185 32 178 38 178 104V397H365V104C365 38 358 32 303 25V0H526V25C451 32 444 37 444 104V397H555C565 404 568 428 563 437H444V471C443 562 453 609 466 629C476 647 492 661 518 661C551 661 581 639 600 620C609 611 619 612 629 620C637 626 647 636 650 644C654 654 654 666 645 677C627 697 597 710 564 712C521 707 476 686 432 642C412 664 374 688 316 690C269 685 230 668 190 636C139 596 120 551 111 525C104 505 99 477 99 449V437ZM365 437H178V461C178 537 192 580 209 605C223 627 245 648 283 648C336 648 374 615 394 585C384 566 378 550 374 533C369 516 365 488 365 456V437Z" id="g190-155"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="561" vert-adv-y="561"></glyph.data></g></svg> function (bottom panel) for transition from (a) <svg height="12.235pt" id="M138" style="vertical-align:-3.27288pt" version="1.1" viewbox="-0.0498162 -8.96212 16.8069 12.235" width="16.8069pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M620 675H597C578 656 570 650 541 650H144C112 650 104 653 94 675H72C59 618 42 552 23 493L53 491C71 534 88 564 105 585C124 608 144 615 238 615H290L197 121C182 40 174 34 88 28L82 0H361L367 28C275 34 266 38 281 121L374 615H441C522 615 543 608 553 583C562 560 566 531 565 493L597 494C603 551 612 629 620 675Z" id="g113-85"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="637" vert-adv-y="637"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,7.176,3.132)"><path d="M380 106C343 72 306 56 265 56C195 56 116 112 115 248C235 252 361 262 377 265C396 269 400 277 400 297C400 374 333 449 250 449H249C198 449 144 421 103 376S37 269 37 201C37 88 109 -12 232 -12C263 -12 332 6 395 84L380 106ZM225 412C281 412 315 364 314 312C314 297 308 292 290 292C232 290 176 289 120 289C135 370 180 412 225 412Z" id="g190-102"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="425" vert-adv-y="425"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,11.044,3.132)"><path d="M99 437H52L25 408L28 397H99V104C99 38 91 32 32 26V0H246V25C185 32 178 38 178 104V397H365V104C365 38 358 32 303 25V0H526V25C451 32 444 37 444 104V397H555C565 404 568 428 563 437H444V471C443 562 453 609 466 629C476 647 492 661 518 661C551 661 581 639 600 620C609 611 619 612 629 620C637 626 647 636 650 644C654 654 654 666 645 677C627 697 597 710 564 712C521 707 476 686 432 642C412 664 374 688 316 690C269 685 230 668 190 636C139 596 120 551 111 525C104 505 99 477 99 449V437ZM365 437H178V461C178 537 192 580 209 605C223 627 245 648 283 648C336 648 374 615 394 585C384 566 378 550 374 533C369 516 365 488 365 456V437Z" id="g190-155"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="561" vert-adv-y="561"></glyph.data></g></svg> = 35°C to 30°C, (b) <svg height="12.235pt" id="M139" style="vertical-align:-3.27288pt" version="1.1" viewbox="-0.0498162 -8.96212 16.8069 12.235" width="16.8069pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M620 675H597C578 656 570 650 541 650H144C112 650 104 653 94 675H72C59 618 42 552 23 493L53 491C71 534 88 564 105 585C124 608 144 615 238 615H290L197 121C182 40 174 34 88 28L82 0H361L367 28C275 34 266 38 281 121L374 615H441C522 615 543 608 553 583C562 560 566 531 565 493L597 494C603 551 612 629 620 675Z" id="g113-85"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="637" vert-adv-y="637"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,7.176,3.132)"><path d="M380 106C343 72 306 56 265 56C195 56 116 112 115 248C235 252 361 262 377 265C396 269 400 277 400 297C400 374 333 449 250 449H249C198 449 144 421 103 376S37 269 37 201C37 88 109 -12 232 -12C263 -12 332 6 395 84L380 106ZM225 412C281 412 315 364 314 312C314 297 308 292 290 292C232 290 176 289 120 289C135 370 180 412 225 412Z" id="g190-102"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="425" vert-adv-y="425"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,11.044,3.132)"><path d="M99 437H52L25 408L28 397H99V104C99 38 91 32 32 26V0H246V25C185 32 178 38 178 104V397H365V104C365 38 358 32 303 25V0H526V25C451 32 444 37 444 104V397H555C565 404 568 428 563 437H444V471C443 562 453 609 466 629C476 647 492 661 518 661C551 661 581 639 600 620C609 611 619 612 629 620C637 626 647 636 650 644C654 654 654 666 645 677C627 697 597 710 564 712C521 707 476 686 432 642C412 664 374 688 316 690C269 685 230 668 190 636C139 596 120 551 111 525C104 505 99 477 99 449V437ZM365 437H178V461C178 537 192 580 209 605C223 627 245 648 283 648C336 648 374 615 394 585C384 566 378 550 374 533C369 516 365 488 365 456V437Z" id="g190-155"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="561" vert-adv-y="561"></glyph.data></g></svg> = 30°C to 25°C, (c) <svg height="12.235pt" id="M140" style="vertical-align:-3.27288pt" version="1.1" viewbox="-0.0498162 -8.96212 16.8069 12.235" width="16.8069pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M620 675H597C578 656 570 650 541 650H144C112 650 104 653 94 675H72C59 618 42 552 23 493L53 491C71 534 88 564 105 585C124 608 144 615 238 615H290L197 121C182 40 174 34 88 28L82 0H361L367 28C275 34 266 38 281 121L374 615H441C522 615 543 608 553 583C562 560 566 531 565 493L597 494C603 551 612 629 620 675Z" id="g113-85"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="637" vert-adv-y="637"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,7.176,3.132)"><path d="M380 106C343 72 306 56 265 56C195 56 116 112 115 248C235 252 361 262 377 265C396 269 400 277 400 297C400 374 333 449 250 449H249C198 449 144 421 103 376S37 269 37 201C37 88 109 -12 232 -12C263 -12 332 6 395 84L380 106ZM225 412C281 412 315 364 314 312C314 297 308 292 290 292C232 290 176 289 120 289C135 370 180 412 225 412Z" id="g190-102"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="425" vert-adv-y="425"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,11.044,3.132)"><path d="M99 437H52L25 408L28 397H99V104C99 38 91 32 32 26V0H246V25C185 32 178 38 178 104V397H365V104C365 38 358 32 303 25V0H526V25C451 32 444 37 444 104V397H555C565 404 568 428 563 437H444V471C443 562 453 609 466 629C476 647 492 661 518 661C551 661 581 639 600 620C609 611 619 612 629 620C637 626 647 636 650 644C654 654 654 666 645 677C627 697 597 710 564 712C521 707 476 686 432 642C412 664 374 688 316 690C269 685 230 668 190 636C139 596 120 551 111 525C104 505 99 477 99 449V437ZM365 437H178V461C178 537 192 580 209 605C223 627 245 648 283 648C336 648 374 615 394 585C384 566 378 550 374 533C369 516 365 488 365 456V437Z" id="g190-155"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="561" vert-adv-y="561"></glyph.data></g></svg> = 25°C to 20°C, and (d) <svg height="12.235pt" id="M141" style="vertical-align:-3.27288pt" version="1.1" viewbox="-0.0498162 -8.96212 16.8069 12.235" width="16.8069pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M620 675H597C578 656 570 650 541 650H144C112 650 104 653 94 675H72C59 618 42 552 23 493L53 491C71 534 88 564 105 585C124 608 144 615 238 615H290L197 121C182 40 174 34 88 28L82 0H361L367 28C275 34 266 38 281 121L374 615H441C522 615 543 608 553 583C562 560 566 531 565 493L597 494C603 551 612 629 620 675Z" id="g113-85"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="637" vert-adv-y="637"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,7.176,3.132)"><path d="M380 106C343 72 306 56 265 56C195 56 116 112 115 248C235 252 361 262 377 265C396 269 400 277 400 297C400 374 333 449 250 449H249C198 449 144 421 103 376S37 269 37 201C37 88 109 -12 232 -12C263 -12 332 6 395 84L380 106ZM225 412C281 412 315 364 314 312C314 297 308 292 290 292C232 290 176 289 120 289C135 370 180 412 225 412Z" id="g190-102"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="425" vert-adv-y="425"></glyph.data></g><g transform="matrix(.0091,0,0,-0.0091,11.044,3.132)"><path d="M99 437H52L25 408L28 397H99V104C99 38 91 32 32 26V0H246V25C185 32 178 38 178 104V397H365V104C365 38 358 32 303 25V0H526V25C451 32 444 37 444 104V397H555C565 404 568 428 563 437H444V471C443 562 453 609 466 629C476 647 492 661 518 661C551 661 581 639 600 620C609 611 619 612 629 620C637 626 647 636 650 644C654 654 654 666 645 677C627 697 597 710 564 712C521 707 476 686 432 642C412 664 374 688 316 690C269 685 230 668 190 636C139 596 120 551 111 525C104 505 99 477 99 449V437ZM365 437H178V461C178 537 192 580 209 605C223 627 245 648 283 648C336 648 374 615 394 585C384 566 378 550 374 533C369 516 365 488 365 456V437Z" id="g190-155"></path><glyph.data ascent="989" descent="-360" horiz-adv-x="561" vert-adv-y="561"></glyph.data></g></svg> = 20°C to 15°C.</div>

Journal of Biophysics

fig11

Figure 11

Figure 11: A Coupled Phase-Temperature Model for Dynamics of Transient Neuronal Signal in Mammals Cold Receptor 