Biochemical and Histological Evaluation of Three Selected Medicinal Plant Extracts of Sri Lankan Origin on Dyslipidemia and Oxidative Stress in Alloxan Induced Diabetic Rats

Table 1

Effect of plant extracts on selected biochemical parameters in alloxan induced diabetic rats after 30 days of treatment.

Parameter tested in blood/serum	Healthy control rats	Diabetic control rats	Diabetic rats treated with G. arborea (1.00 g/kg)	Diabetic rats treated with S. pinnata (1.00 g/kg)	Diabetic rats treated with C. grandis (0.75 g/kg)	Diabetic rats treated with glibenclamide (0.50 mg/kg)
Hb (%)	4.8±0.2	9.8±0.1	6.7±0.	6.9±0.	6.3±0.	5.6±0.
Insulin (µIU/mL)	14.8±0.1	6.0±0.1	8.7±0.	8.0±0.	10.4±	11.0±0.
C-peptide (ng/mL)	9.4±0.1	5.3± 0.1	7.7±0.	6.6±0.	8.1±0.	8.6±0.
TC (mmol/L)	3.8±0.2	6.0±0.0	4.0±0.	4.7±0.	4.8±0.	3.8±0.
HDL-C (mmol/L)	1.1±0.1	1.0±0.1	1.3±0.	1.4±0.	1.4±0.	1.0±0
TG (mmol/L)	0.2±0.1	0.4±0.2	1.5±0.	1.6±0.	1.7±0.	1.2±0.
LDL-C (mmol/L)	1.1±0.1	2.1±0.1	2.4±0.	3.2±0.	3.2±0.	2.5±0.
VLDL-C (mmol/L)	2.4±0.1	4.5±0.1	0.3±0.	0.2±0.	0.3±0.	0.2±0.
AI	2.4	5.0	2.07	2.51	2.43	2.8
CRI	3.4	6.0	3.10	3.21	3.32	3.8
CPI	1.0	0.5	0.54	0.5	0.4	0.4
ALT (U/L)	13.1±0.1	20.7±1.1	12.8±0.	16.0±0.	14.8±0.	18.3±0.
AST (U/L)	43.6±1.0	66.1±1.9	49.5±1.	60.1±1.	53.3±1.	63.0±0.
ALP (U/L)	63.3±0.5	108.2±1.1	78.0±1.	73.1±2.	74.9±1.	104.7±1.
GSH (µg/g liver)	712.8±7.4	474.0±8.7	612.3±7.	572.1±4.	577.0±8.	584.6±11.
GR (nmol/min/mg of protein)	9.0±1.6	4.9±0.4	7.3±1.	7.0±0.	7.1±0.	5.4±0.
GPx (nmol/min/mg of protein)	10.1±0.9	5.7±0.1	7.0±0.	6.2±0.	7.0±0.6	6.6±0.
GST (nmol/min/mg of protein)	10.5±1.4	5.0±0.1	8.5±1.	7.5±0.	7.4±0.9	5.4±0.
MDA (nmol/mg protein)	11.0±0.3	29.0±1.8	16.1±1.	24.1±2.	21.3±2.	17.6±1.

: glycated haemoglobin, TC: total cholesterol, HDL-C: high density lipoprotein cholesterol, TG: triglyceride, LDL-C: low density lipoprotein cholesterol, VLDL-C: very low density lipoprotein cholesterol, ALT: alanine aminotransferase, AST: aspartate aminotransferase, ALP: alkaline phosphatase, GSH: reduced glutathione, GR: glutathione reductase, GPx: glutathione peroxidase, GST: glutathione S-transferase, MDA: malondialdehyde, AI: atherogenic index, CRI: coronary risk index, and CPI: cardio protective index. The values are expressed as mean ± SEM (n=6/group). significant from alloxan induced diabetic control rats at p<0.05 (ANOVA followed by Dunnett’s test).