Journal of Aging Research

Mitochondria and Ageing


Publishing date
15 Apr 2011
Status
Published
Submission deadline
15 Oct 2010

Lead Editor

1Institute of Medical Technology, University of Tampere and Tampere University Hospital, 33500 Tampere, Finland

2Department of Experimental Medicine, University of Lleida, IRB Lleida, 25008 Lleida, Spain

3Department of Aging and Geriatric Research, University of Florida, Gainesville, FL 32611, USA


Mitochondria and Ageing

Description

During the last 20 years, the Mitochondrial Theory of Ageing (MTA) has been one of the most supported theories to explain ageing. Different animal models (Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, and Mus musculus) support the hypothesis that mitochondria play an essential role in ageing process; however there is a lot of controversy about the mechanism by how they influence on longevity. Several explanations (some time contradictory, some time complementary) have been proposed. The most supported are based on free radical chemistry, alterations of redox homeostasis, deficits in ATP production, deregulation of apoptosis, and the accumulation of mutations in the mitochondrial DNA. The understanding of ageing phenomenon requires determining the role mitochondria play on it, discerning if the alteration in mitochondrial function associated to ageing is a cause or a consequence of it.

We invite researchers to contribute with original research articles as well as review articles that will help to understand the biochemical, molecular, and physiological mechanisms behind ageing, as well as new strategies to delay or even reverse the ageing process increasing the numbers of healthy years. We are particularly interested in articles dealing with the role mitochondria play in ageing (passive or active), and particularly in the accumulation of mutations in mitochondrial DNA, the regulation of mitochondrial free radical production, and the discovery of new signaling pathways in the crosstalk between nuclei and mitochondria. In addition, articles focusing in new techniques to measure mutations rate in mitochondrial DNA and generation of oxidative damage (including ROS production) in vivo would be greatly appreciated.

Potential topics include, but not limited to:

  • Ageing and evolution
  • Oxidative stress markers of ageing
  • Crosstalking between the nucleus and mitochondria
  • Cancer and mitochondria
  • New techniques for the measurement of free radical generation in vivo
  • New techniques to evaluate the accumulation of mutations in mtDNA
  • Therapies to delay aging
  • Therapies to reverse aging

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jar/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2011
  • - Article ID 782946
  • - Editorial

Mitochondria and Ageing

Christiaan Leeuwenburgh | Reinald Pamplona | Alberto Sanz
  • Special Issue
  • - Volume 2011
  • - Article ID 845379
  • - Research Article

Morphofunctional and Biochemical Approaches for Studying Mitochondrial Changes during Myoblasts Differentiation

Elena Barbieri | Michela Battistelli | ... | Elisabetta Falcieri
  • Special Issue
  • - Volume 2011
  • - Article ID 810619
  • - Review Article

Mitochondria and PGC-1α in Aging and Age-Associated Diseases

Tina Wenz
  • Special Issue
  • - Volume 2011
  • - Article ID 673185
  • - Research Article

Identification of Potential Calorie Restriction-Mimicking Yeast Mutants with Increased Mitochondrial Respiratory Chain and Nitric Oxide Levels

Bin Li | Craig Skinner | ... | Su-Ju Lin
  • Special Issue
  • - Volume 2011
  • - Article ID 407536
  • - Review Article

The Importance of Mitochondrial DNA in Aging and Cancer

Claus Desler | Maiken Lise Marcker | ... | Lene Juel Rasmussen
  • Special Issue
  • - Volume 2011
  • - Article ID 920178
  • - Review Article

IP3 Receptors, Mitochondria, and Ca2+ Signaling: Implications for Aging

Jean-Paul Decuypere | Giovanni Monaco | ... | Geert Bultynck
  • Special Issue
  • - Volume 2011
  • - Article ID 234875
  • - Review Article

Mitochondrial Acetylation and Diseases of Aging

Gregory R. Wagner | R. Mark Payne
  • Special Issue
  • - Volume 2011
  • - Article ID 908035
  • - Review Article

Proteomic Profiling of Mitochondrial Enzymes during Skeletal Muscle Aging

Lisa Staunton | Kathleen O'Connell | Kay Ohlendieck
  • Special Issue
  • - Volume 2011
  • - Article ID 820903
  • - Review Article

Therapeutic Approaches to Delay the Onset of Alzheimer's Disease

Raj Kumar | Hani Atamna
  • Special Issue
  • - Volume 2011
  • - Article ID 136435
  • - Review Article

The Role of the Mitochondrial Genome in Ageing and Carcinogenesis

Anna M. Czarnecka | Ewa Bartnik
Journal of Aging Research
 Journal metrics
Acceptance rate27%
Submission to final decision114 days
Acceptance to publication46 days
CiteScore1.680
Impact Factor-
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