The recent economic crisis and the current epidemiological trends of western populations highlighted how the current health care systems are inadequate to respond to the evolution of population needs. Among the most important societal challenges is aging that often is associated with frailty, chronic diseases, and increased multimorbidity. The perspective cost of an aging society will not be sustainable in terms of health care and social services, unless they are reorganized with a focus on prevention and health promotion in an integrated system. Innovation will be the driver able to turn a burden into an opportunity. The present issue is aimed at collecting original contributions and reviews that tackle aging in its multiple dimensions.

Potential topics include but are not limited to the following:

• Prevention, early diagnosis, and health promotion, including physical training
• Informal caregivers: relevance and impacts
• Integrated management of chronic diseases, with a focus on ICT solutions to support health care pathways and sociosanitary services
• Multimorbidity and prescription adherence
• Research models and molecular determinants of frailty and frailty-related conditions
• Architecture solutions to support active aging and independent living, including falls prevention
• Business models to monitor cost and benefits of the innovative services set up to promote active and healthy aging