Melamine Exacerbates Neurotoxicity in D-Galactose-Induced Neuronal SH-SY5Y Cells

Figure 1

Melamine-induced cell death in a dose-dependent manner. (a) Melamine cytotoxicity. SH-SY5Y cells were treated with different concentrations of melamine for 72 h. Cytotoxicity was assessed through MTT assay. Data are reported as mean ± SEM. Statistically significant differences are indicated as  < 0.01 compared to the control group. (b) The effect of Melamine on cell proliferation following D-galactose-induced toxicity. SH-SY5Y cells were treated individually and in combination with melamine and D-galactose for 72 h. Another group of cells was treated only with glucose for 72 h. Cytotoxicity was evaluated using MTT assay. Data are reported as mean ± SEM. Statistically significant differences are indicated as  < 0.01 compared to the control group, ^## < 0.01 compared to the melamine group, ^‡‡ < 0.01 and ^‡ < 0.05 compared to the D-galactose group, and ^¥¥ < 0.01 compared to the glucose group.

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