Association of Social Engagement with Brain Volumes Assessed by Structural MRI

Table 2

Adjusted associations between social engagement (independent variable) and ROI volumes (dependent variables).

ROI	Mean volume (cc)	Social engagement standardized coefficient	𝑃 value
Total brain volume	1137.96	0.037	0.011
Total gray matter (GM)	534.14	0.072	0.007
Total white matter (WM)	603.82	0.001	0.975
Gray matter lobes
Frontal GM	134.85	0.037	0.273
Temporal GM	96.58	0.083	0.009
Parietal GM	65.40	0.068	0.081
Occipital GM	45.56	0.076	0.048
White matter lobes
Frontal WM	201.47	0.008	0.761
Temporal WM	119.03	0.021	0.501
Parietal WM	106.08	0.026	0.456
Occipital WM	58.22	0.007	0.869
Smaller structures
Cerebellum	119.63	−0.013	0.763
Medial structures	80.63	0.047	0.135
Cingulate gyrus	21.02	0.045	0.269
Insula	13.94	0.008	0.865
Corpus callosum	11.89	0.127	0.004
Internal capsule	9.85	0.026	0.520
Hippocampus	7.42	−0.004	0.923
Amygdala	2.43	0.037	0.453
Entorhinal cortex	2.37	−0.016	0.756

From models adjusted for age, education, intracranial volume, race/ethnicity, hypertension, diabetes, handedness, and control status.
Bold: 𝑃≤0.05.