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Proteomic study | Changes in mitochondrial marker proteins | Reference |
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Analysis of total extracts from aged human vastus lateralis muscle | General increase in aerobic markers, including mitochondrial enzymes such as ATP synthase, ubiquinol-cytochrome c reductase, and oxoglutarate dehydrogenase during muscle aging | Gelfi et al. [86] |
Analysis of total extracts from rat gastrocnemius muscle | Increase in mitochondrial enzymes, such as succinate dehydrogenase, isocitrate dehydrogenase, ATP synthase, and malate dehydrogenase during muscle aging | Doran et al. [93] |
Analysis of total extracts from rat gastrocnemius muscle | Differential effect on the abundance of mitochondrial isoforms of aconitase during muscle aging | O’Connell et al. [87] |
Analysis of total extracts from aged rat gastrocnemius muscle | Moderate effect on cytochrome c oxidase and isocitrate dehydrogenase during muscle aging | Piec et al. [85] |
Analysis of total extracts from rat gastrocnemius muscle | Increase in many enzymes involved in oxidative metabolism, such as ATP synthase, isocitrate dehydrogenase, ubiquinol-cytochrome c reductase, and pyruvate dehydrogenase during muscle aging | Capitanio et al. [94] |
Subproteomic study of the effect of aging and caloric restriction on rat muscle mitochondria | Increased levels of isocitrate dehydrogenase and malate dehydrogenase in aged muscle mitochondria. Caloric restriction appears to have only a marginal effect on the mitochondrial proteome | Chang et al. [90] |
Subproteomic analysis of mitochondria-enriched fraction from aged rat gastrocnemius muscle | Increased levels of mitochondrial creatine kinase, NADH dehydrogenase, ATP synthase, succinate dehydrogenase, and ubiquinol cytochrome c reductase during muscle aging |
O’Connell and Ohlendieck [97] |
Analysis of total extracts and mitochondria-enriched fraction from aged ratgastrocnemius muscle | Differential effect on mitochondrial enzymes, such as pyruvate dehyrdogenase, cytochrome c oxidase, isocitrate dehydrogenase, and ATP synthase during muscle aging | Lombardi et al. [96] |
Subproteomic analysis of mitochondria-enriched fraction from aged mouse hind limb muscles | Differential effects on the abundance and carbonylation of various mitochondrial enzymes, including NADH dehydrogenase, cytochrome c oxidase, and ATP synthase during muscle aging | Alves et al. [98] |
Analysis of detergent phase-extracted protein complement from aged rat gastrocnemius muscle | Increase in mitochondrial marker enzymes, such as ATP synthase and isocitrate dehydrogenase during muscle aging | Donoghue et al. [99] |
Proteomic analysis of nitration in aged rat skeletal muscle | Increased nitration levels in succinate dehydrogenase | Kanski et al. [84] |
Phosphoproteomic analysis of total extracts from aged rat gastrocnemius muscle | Decreased phosphorylation levels in cytochrome c oxidase and aconitase during muscle aging | Gannon et al. [92] |
Proteomic analysis of carbonylation in aged rat skeletal muscle mitochondria | Altered carbonylation levels in numerous mitochondrial proteins, including ATP synthase, NADH dehydrogenase, pyruvate dehydrogenase, and isocitrate dehydrogenase during muscle aging | Feng et al. [91] |
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