TY - JOUR A2 - Sanz, Alberto AU - Staunton, Lisa AU - O'Connell, Kathleen AU - Ohlendieck, Kay PY - 2011 DA - 2011/03/07 TI - Proteomic Profiling of Mitochondrial Enzymes during Skeletal Muscle Aging SP - 908035 VL - 2011 AB - Mitochondria are of central importance for energy generation in skeletal muscles. Expression changes or functional alterations in mitochondrial enzymes play a key role during myogenesis, fibre maturation, and various neuromuscular pathologies, as well as natural fibre aging. Mass spectrometry-based proteomics suggests itself as a convenient large-scale and high-throughput approach to catalogue the mitochondrial protein complement and determine global changes during health and disease. This paper gives a brief overview of the relatively new field of mitochondrial proteomics and discusses the findings from recent proteomic surveys of mitochondrial elements in aged skeletal muscles. Changes in the abundance, biochemical activity, subcellular localization, and/or posttranslational modifications in key mitochondrial enzymes might be useful as novel biomarkers of aging. In the long term, this may advance diagnostic procedures, improve the monitoring of disease progression, help in the testing of side effects due to new drug regimes, and enhance our molecular understanding of age-related muscle degeneration. SN - 2090-2204 UR - https://doi.org/10.4061/2011/908035 DO - 10.4061/2011/908035 JF - Journal of Aging Research PB - SAGE-Hindawi Access to Research KW - ER -