Self-Renewal Signalling in Presenescent Tetraploid IMR90 Cells
Figure 1
Phenotypic characteristics of IMR90 in the process of senescing showing cell enlargement and the accumulation of principal growth inhibitors involved in the regulation of senescence, p16 and p21, in three stages: ((a), (d)) presenescence, ((b), (e)) senescence, ((c), (f)) degeneration phase. ((a)–(c)) p16 (red) and DAPI (blue); ((d)–(f)) p21(red) and DAPI (blue). Scale bar = 20 μm.
