Significant progress has been made over the last few decades in the analysis of biomolecules. The characterization of complex biological macromolecules such as proteins, DNA, RNA, carbohydrates, and lipids using various analytical techniques was initiated in the 19th century. Scientists developed simple separation methods such as crystallization and acidification in order to isolate purified DNA and performed many studies to understand its structure. The discovery of DNA structure has provoked many scientists to develop various bioanalytical techniques for the analysis of DNA that are considered vital tools to understand complex DNA interactions and other cellular processes. Recently, major accomplishments have been reported in developing various analytical tools to solve challenging biological problems such as identifying various potential diagnostic and therapeutic biomarkers for personalized treatment, which is a vital step in the field of drug discovery and development.

Many analytical methods are currently available for the sensitive detection of DNA. However, they suffer from many limitations such as involving multi-steps and complex procedures, being time-consuming and labour-intensive, requiring expensive instruments and reagents, in addition to destroying the sample.

The goal of this Special Issue is to report various advances in bioanalytical technologies for the sensitive detection of various DNA samples. For example, the routine analysis of DNA samples, and reports describing simple, inexpensive, mix-and-read assays and methods that are automated, real-time, reliable, reproducible, and cost-effective for the accurate monitoring and detection of DNA molecules. Original research and review articles are welcome.

Potential topics include but are not limited to the following:

• Electrochemical DNA biosensors
• Spectroscopic probes for DNA detection
• In vitro and in vivo detection of specific DNA sequences
• Pharmacogenomics
• Quantification of DNA damage
• Nano/micro-scale detection of damaged DNA
• Nucleotide polymorphism analysis
• Selective probing for DNA mismatches
• Chromatographic detection of different biomolecules
• Determination of the effect of different chemicals on DNA integrity
• Recent applications of aptamer in biosensors fabrication