Analytical chemistry has always played an important role in the field of medicine. It helps physicians diagnose and understand diseases and analyze biological samples such as enzymes, bacteria, and blood. There are many applications of using analytical techniques in various fields of medicine to help characterize diseases with a view of developing rapid diagnostic techniques. Several analytical approaches allow for tracking metabolic pathways to monitor the efficacy of therapeutic treatments and their impact on the body. Some non-invasive methodologies use biomarkers in saliva and breath to identify certain diseases and disorders. In addition, analytical chemistry uses instrumentation, wet chemistry methods, and statistics to understand certain medical samples and diseases, which also aids in medical research and pharmaceutical development.

How to detect ions and molecules related to human health with high sensitivity has always been an important topic in analytical chemistry. Different methodologies have been developed to overcome the remaining challenges. Today, the field is increasingly benefiting from advances in other fields, such as materials science and instrumentation science. The combination of different methodologies is also becoming a hot topic. This topic in particular faces the challenge of how to design ultrasensitive and low-cost analysis methods.

This Special Issue aims to highlight recent advancements in the detection of health-related analytes via different analytical technologies such as electrochemical analysis, immunoassay, colorimetric analysis, electrophoresis, fluorescence analysis, etc. We welcome original research and review articles.

Potential topics include but are not limited to the following:

• Screening/identification of drugs via analytical methods
• Point-of-care diagnostics, microfluidics, cellular analysis
• Application of novel approaches for the determination of analytes in biological samples
• Instrumental advancements or novel methods for the detection of new illicit drugs or metabolites
• Articles covering novel approaches with regards to baseline correction, noise removal, background elimination, differentiation, data smoothing, and filtering, data compression, separation of overlapping signals, multiresolution analysis, analytical images processing, and modeling of multivariate datasets in analytical chemistry
• Immobilization strategies to improve the long-term stability of hybridization-based biosensors
• Affordable biosensor platforms such as paper or pin-based devices
• New trends in sample preparation and analytical determinations
• Enzyme-coupled assays for the kinetic evaluation and engineering of enzymes
• Characterization of electrochemical sensors and biosensors using physical, chemical, microscopic, and electrochemical techniques
• Design of electrochemical sensors and biosensors that detect multicomponent medical and pharmaceutical samples
• Validation of electrochemical sensors and biosensors during pharmaceutical or medical analysis