Simultaneous Determination of Three Compounds in Rat Plasma by UHPLC-QQQ-MS/MS and Its Application to Pharmacokinetics of Banxia Baizhu Tianma Tang

Table 5

Mean pharmacokinetic parameters of ephedrine, gastrodin, and liquiritin in rat plasma after intragastric administration of Banxia Baizhu Tianma Tang solution of 16.6 mL/kg, equivalent to 28 mg/kg of ephedrine, 10 mg/kg of gastrodin, and 9 mg/kg of liquiritin, respectively (mean ± SD, n = 6).

Analytes	Parameters
	Tmax (h)^b	Cmax (ng/mL)^b	t1/2 (h)^b	Vd (L/kg)^a	CL (L h/kg)^a	AUC0⟶t (ng/mL) h^a	AUC0⟶∞ (ng/mL) h^a
Ephedrine	0.917 ± 0.144	128.2 ± 28.8	2.639 ± 0.574	284.04 ± 52.7	106.6 ± 18.9	262.2 ± 42.2	267.81 ± 43.29
Gastrodin	0.5 ± 0.0	1622.7 ± 657.3	1.278 ± 0.48	4.904 ± 3.171	4.057 ± 2.146	2483.5 ± 1194.0	3012.89 ± 1630.6
Liquiritin	0.167 ± 0.0	244.7 ± 64.2	2.176 ± 0.332	3436.2 ± 1485.4	34.4 ± 14.9	230.3 ± 135.5	314.0 ± 180.8

a and b are the compartmental and non-compartmental approaches, respectively.