Chemometric Methods for Simultaneous Determination of Candesartan Cilexetil and Hydrochlorothiazide in Binary Combinations

Table 19

The review of the published work for simultaneous determination of drugs by different chemical methods.

No	Method	Drug	Linear range (μg/ml)	RSD%	Recovery%	LOD (μg/ml)	Reference
1	Spectrophotometric	CAN	2.5–50	1.19	99.0	0.55	[45]
		HCT	1–30	0.74	99.0	0.32
2	UV-spectrophotometric	CAN	2–24	0.205	101.2	—	[46]
		HCT	2–24	0.154	99.2	—
3	RP-HPLC	CAN	6.25–18.75	—	99.78	0.410	[47]
		HCT	8–24	—	100.64	0.699
4	Proposed methods (HPSAM)	CAN	1–46	0.2061	98.84	0.48	—
		HCT	1–44	0.3084	98.9	0.46
5	Proposed methods (Q-absorption ratio)	CAN	1–46	0.09338	99.93	0.88	—
		HCT	1–44	0.1813	99.2	0.76
6	Proposed methods (correction absorbance)	CAN	1–46	0.2273	100.33		—
		HCT	1–44	0.2226	100.73