Chemometric Methods for Simultaneous Determination of Candesartan Cilexetil and Hydrochlorothiazide in Binary Combinations

Table 10

Precision of the H-point standard addition method in the determination of HCT and CAN.

λ	Regression equation	R^2	Added (µg/mL)		Found (µg/mL)
			HCT	CAN	HCT	CAN
283	Y = 0.01103X + 0.5816	0.9944	15	15	15.12	14.98
239	Y = 0.03188X + 0.8939	0.9989
283	Y = 0.01096X + 0.5688	0.9945	15	15	14.75	14.86
239	Y = 0.03194X + 0.8805	0.9985
283	Y = 0.01141X + 0.5638	0.9917	15	15	14.43	14.59
239	Y = 0.03260X + 0.8730	0.9974
283	Y = 0.01108X + 0.5719	0.9941	15	15	14.71	15.06
239	Y = 0.03187X + 0.8850	0.9989
283	Y = 0.01103X + 0.5793	0.9944	15	15	15.17	14.64
239	Y = 0.03186X + 0.8843	0.9989
Mean					14.84	14.83
SD					0.3084	0.2061
RSD(n = 5)					2.08	1.39
%R					98.9	98.84

¹ calculated using the regression equation of Y = 0.0247x + 0.0297 and the HCT calibration curve at 283 nm.