A Reliable and Effective UPLC-MS/MS Method for the Determination of Oprozomib in Rat Plasma

Table 3

Stability results of oprozomib in plasma under different conditions (n = 5).

Analyte	Concentration added (ng/mL)	Room temperature, 3 h		Autosampler 10°C, 4 h		Three freeze-thaw		−80°C, 3 weeks
		RSD (%)	RE (%)	RSD (%)	RE (%)	RSD (%)	RE (%)	RSD (%)	RE (%)
Oprozomib	2.0	6.2	10.7	6.7	−13.3	7.1	11.3	4.2	−0.2
	40	2.2	−1.2	3.7	−0.3	2.6	2.8	4.2	1.5
	80	6.3	8.5	3.6	1.1	6.3	13.7	7.6	13.5

RSD: relative standard deviation; RE: relative error.