A Simple and Sensitive HPLC-MS/MS Assay for the Quantitation of Blonanserin and N-Desethyl Blonanserin in Rat Plasma and Its Application to Pharmacokinetic Study

Table 2

Extraction recovery and matrix effect results of blonanserin and N-desethyl blonanserin in rat plasma (mean ± SD, n = 6).

Analyte	Concentration (ng·mL^−1)	Extraction recovery (%, ± s)	CV (%)	IS-normalized matrix effect (% ± s)	RSD (%)
Blonanserin	0.3	91.41 ± 6.39	6.99	65.75 ± 2.98	4.53
	30.0	87.06 ± 4.56	5.23	55.73 ± 1.61	2.89
	75.0	87.73 ± 2.69	3.07	53.35 ± 2.36	4.43
N-desethyl blonanserin	0.3	95.39 ± 9.74	10.21	105.22 ± 2.38	2.27
	30.0	92.55 ± 2.12	2.29	102.33 ± 3.60	3.52
	75.0	94.10 ± 2.83	3.01	97.62 ± 2.06	2.11