Pharmacokinetic Analysis of Diosgenin in Rat Plasma by a UPLC-MS/MS Approach

Table 4

Pharmacokinetic parameters following oral administration of diosgenin and its ASD (mean ± SD, n = 6).

Parameter	Diosgenin	ASD
AUC0-t (μg/lh)	9,302.27 ± 5,013.38	42,972.58 ± 6,864.96
AUC0-∞ (μg/lh)	9,598.01 ± 5,151.91	43,490.51 ± 7,648.62
MRT0- t (h)	22.77 ± 5.55	21.05 ± 4.30
t1/2z (h)	12.33 ± 3.02	10.67 ± 2.59
Tmax (h)	8.73 ± 5.74	10.07 ± 3.65
CLz/F (L/h/kg)	12.41 ± 6.13	3.20 ± 0.63
Vz/F (L/kg)	231.16 ± 161.21	44.18 ± 6.78
Cmax (μg/l)	480.09 ± 121.31	1,281.65 ± 262.08

Compared with diosgenin, ,.