Pharmacokinetic Analysis of Diosgenin in Rat Plasma by a UPLC-MS/MS Approach

Table 1

Extraction recovery and the matrix effect of diosgenin and IS on plasma determined by UPLC-MS/MS (n = 6).

	Concentration (ng/ml)	Extraction recovery		Matrix effect
		Mean (%)	RSD (%)	Mean (%)	RSD (%)
Diosgenin	5	85.81	5.83	93.22	3.63
	50	86.66	6.49	92.36	4.12
	1000	100.27	5.75	93.07	3.47
IS	42	98.29	6.09	95.56	2.28