Determination of Tropifexor in Beagle Dog Plasma by UPLC-MS/MS and Its Application in Pharmacokinetics

Table 5

The major pharmacokinetic parameters ascribed to tropifexor in beagles (n = 6, Mean ± SD).

Parameters	Unit	Tropifexor
C max	ng/mL	76.87 ± 17.26
T max	h	3.33 ± 0.52
t 1/2	h	9.27 ± 2.63
CLz/F	L/h/kg	0.53 ± 0.16
AUC(0⟶t)	ng·h/mL	664.52 ± 229.21
AUC(0⟶∞)	ng·h/mL	685.96 ± 232.57