Determination of Tropifexor in Beagle Dog Plasma by UPLC-MS/MS and Its Application in Pharmacokinetics

Table 2

The accuracy and precision of tropifexor in Beagle plasma (n = 6).

Added (ng/mL)	Intraday			Interday
	Found (ng/mL)	RSD (%)	RE (%)	Found (ng/mL)	RSD (%)	RE (%)
1	0.99 ± 0.07	7.31	−1.00	0.95 ± 0.02	2.22	−4.89
2.5	2.50 ± 0.15	5.86	0.07	2.49 ± 0.06	2.43	−0.44
50	49.63 ± 2.14	4.31	−0.75	50.58 ± 0.57	1.14	1.16
150	149.74 ± 3.91	2.55	−0.17	150.66 ± 0.84	0.56	0.44