Systematic Identification, Fragmentation Pattern, And Metabolic Pathways of Hyperoside in Rat Plasma, Urine, And Feces by UPLC-Q-Exactive Orbitrap MS

Table 2

Metabolic reactions of hyperoside in rat plasma, urine and feces.

Metabolic type	Reaction type	Changes in the group	Number of metabolites
Phase I metabolism	Glycoside hydrolysis	−C6H10O5	21
	Hydroxylation	+O	5
	Dehydroxylation	−O	2
	Hydrogenation	+H2	5
	Hydration	+H2O	1
Phase II metabolism	Methylation	+CH2	7
	Acetylation	+C2H2O	2
	Glucuronide conjugation	+C6H8O6	14
	Sulfation	+SO3	7