Pharmacokinetic Study of Coadministration with Cefuroxime Sodium for Injection Influencing ReDuNing Injection-Derived Seven Phytochemicals and Nine Metabolites in Rats

Table 6

The pharmacokinetic parameters of the compounds in rat plasma after intravenous coadministration of RDN and CNa.

Compound	Group	AUC(0-t)	T1/2	Cmax	CL
		(ng/mL  h)	(h)	(ng/mL)	(L/h/kg)
Geniposide	1 (RDN-1)	15882 ± 2455	0.50 ± 0.13	42673 ± 3368	1266 ± 181
	3 (RDN/CNa-1)	13576 ± 568^a	0.27 ± 0.03^a	31243 ± 3242^a	1461 ± 64^a
	4 (RDN-5)	10735 ± 1306	0.36 ± 0.03	31584 ± 5073	1639 ± 215
	5 (CNA-4 + RDN-1)	8870 ± 541^d	0.23 ± 0.05^d	24702 ± 3662^d	2129 ± 204^d
	6 (RDN/CNA-4 + RDN-1)	4590 ± 604^e	0.21 ± 0.02^e	18042 ± 2915^e	4268 ± 580^e
	8 (RDN/CNA-5)	10482 ± 1137^c	0.17 ± 0.07^b,c	35357 ± 4441	1871 ± 237^c
Shanzhiside	1 (RDN-1)	2926 ± 423	0.40 ± 0.04	4816 ± 908	193 ± 28
	3 (RDN/CNA-1)	2318 ± 216^a	0.58 ± 0.08^a	4124 ± 324	218 ± 43
	4 (RDN-5)	3089 ± 463	0.53 ± 0.10	4972 ± 578	175 ± 27
	5 (CNA-4 + RDN-1)	2251 ± 238^d	0.26 ± 0.03^d	3344 ± 541^d	231 ± 47^d
	6 (RDN/CNA-4 + RDN-1)	1392 ± 132^e	0.38 ± 0.04^e	2920 ± 202^e	405 ± 40^e
	8 (RDN/CNA-5)	1503 ± 104^b,c	0.63 ± 0.09	3358 ± 643^b,c	356 ± 23^b,c
Genipin-1-β-gentiobioside	1 (RDN-1)	5454 ± 515	0.29 ± 0.07	17337 ± 2898	1802 ± 219
	3(RDN/CNA-1)	5025 ± 648	0.17 ± 0.03^a	11673 ± 964^a	2092 ± 261
	4 (RDN-5)	4878 ± 360	0.17 ± 0.03	14540 ± 1994	1757 ± 333
	5 (CNA-4 + RDN-1)	2844 ± 340^d	0.41 ± 0.17^d	7593 ± 1412^d	3084 ± 651^d
	6 (RDN/CNA-4 + RDN-1)	1894 ± 270^e	0.23 ± 0.04^e	8800 ± 1676^e	5102 ± 873^e
	8 (RDN/CNA-5)	3010 ± 245^b,c	0.24 ± 0.03^b,c	11448 ± 1954^b	2857 ± 786^b,c
Secoxyloganin	1 (RDN-1)	4363 ± 481	0.34 ± 0.07	15334 ± 3324	466 ± 49
	3 (RDN/CNA-1)	4319 ± 647	0.50 ± 0.14^a	13063 ± 1283	347 ± 72^a
	4 (RDN-5)	4414 ± 454	0.40 ± 0.08	12893 ± 2938	431 ± 33
	5 (CNA-4 + RDN-1)	3056 ± 369^d	0.29 ± 0.10	8625 ± 1680^d	546 ± 110^d
	6 (RDN/CNA-4 + RDN-1)	2291 ± 293^e	0.35 ± 0.04	10509 ± 1878	785 ± 82^e
	8 (RDN/CNA-5)	2982 ± 337^b,c	0.27 ± 0.06^b,c	10878 ± 2123	645 ± 98^b,c
Neochlorogenic acid	1 (RDN-1)	3432 ± 541	0.16 ± 0.03	17113 ± 2866	2223 ± 293
	3 (RDN/CNA-1)	6631 ± 443^a	0.15 ± 0.06	21577 ± 2564^a	1172 ± 89^a
	4 (RDN-5)	4639 ± 413	0.23 ± 0.10	22059 ± 2157	1528 ± 205
	5(CNA-4 + RDN-1)	1401 ± 191^d	0.25 ± 0.05	6228 ± 1209^d	4958 ± 626
	6 (RDN/CNA-4 + RDN-1)	1762 ± 240^e	0.13 ± 0.02^e	10871 ± 1093^e	4310 ± 505.1^e
	8 (RDN/CNA-5)	3259 ± 301^b,c	0.15 ± 0.02	15385 ± 2881^b,c	2350 ± 202^b,c
Chlorogenic acid	1 (RDN-1)	2973 ± 307	0.35 ± 0.20	12047 ± 2071	3378 ± 562
	3 (RDN/CNA-1)	6350 ± 420^a	0.22 ± 0.10	25083 ± 3526^a	1758 ± 240^a
	4 (RDN-5)	5614 ± 644	0.14 ± 0.03	25312 ± 3764	2190 ± 294
	5 (CNA-4 + RDN-1)	1018 ± 134^d	0.13 ± 0.02	5077 ± 965^d	12262 ± 1517^d
	6 (RDN/CNA-4 + RDN-1)	1639 ± 263^e	0.17 ± 0.04	9417 ± 1926^e	7507 ± 1183^e
	8 (RDN/CNA-5)	3998 ± 341^b,c	0.16 ± 0.06	22140 ± 1861	3038 ± 327^b,c
Cryptochlorogenic acid	1 (RDN-1)	2358 ± 249	0.24 ± 0.04	9650 ± 1207	3039 ± 325
	3 (RDN/CNA-1)	5080 ± 265^a	0.21 ± 0.06	19946 ± 3024^a	1426 ± 142^a
	4 (RDN-5)	4824 ± 577	0.19 ± 0.03	18894 ± 2701	1554 ± 185
	5 (CNA-4 + RDN-1)	894 ± 97^d	0.21 ± 0.06	3856 ± 565^d	8353 ± 1052^d
	6 (RDN/CNA-4 + RDN-1)	1424 ± 192^e	0.19 ± 0.01	7679 ± 1253^e	5421 ± 768^e
	8 (RDN/CNA-5)	3100 ± 370^b,c	0.15 ± 0.06	16484 ± 2279^c	2551 ± 396^b,c
Cefuroxime	2 (CNa-1)	258567 ± 16978	0.36 ± 0.05	318320 ± 34982	780 ± 111
	3 (RDN/CNa-1)	199337 ± 14691^f	0.41 ± 0.05	358284 ± 31456	1095 ± 94^f
	7 (CNa-5)	197432 ± 16765	0.27 ± 0.09	492963 ± 47916	1136 ± 93
	8 (RDN/CNa-5)	184016 ± 17314	0.25 ± 0.04	438024 ± 81058	1226 ± 119

^a, Group 1 vs Group 3; ^b, Group 3 vs Group 6; ^c, Group 2 vs Group 6; ^d, Group 3 vs Group 4; ^e; Group 3 vs Group 5 and ^f; Group 2 vs Group 7.