Pharmacokinetic Study of Coadministration with Cefuroxime Sodium for Injection Influencing ReDuNing Injection-Derived Seven Phytochemicals and Nine Metabolites in Rats

Table 5

The stabilities of seven analytes with cefuroxime of QC samples in rat plasma under different storage conditions.

Analyte	Concentration (ng/mL)	Three freeze–thaw cycles (mean ± SD, (%))	Long-term stability −20°C for 21 d (mean ± SD, (%))	Short-term stability 25°C for 4 h (mean ± SD, (%))	Post-prepared sample 4°C for 24 h (mean ± SD, (%))
Geniposide	77	97.47 ± 4.39	97.81 ± 3.11	93.43 ± 3.99	97.78 ± 3.83
	3095	92.72 ± 4.92	89.66 ± 2.33	97.65 ± 3.28	95.15 ± 4.62
	49523	95.19 ± 5.96	91.13 ± 2.39	91.08 ± 3.69	100.12 ± 1.04
Shanzhiside	10	92.17 ± 5.06	96.72 ± 3.16	90.38 ± 2.82	92.34 ± 1.57
	389	94.14 ± 3.27	90.92 ± 2.53	93.13 ± 5.65	92.08 ± 4.82
	6229	100.24 ± 8.32	101.27 ± 10.32	95.45 ± 6.94	98.14 ± 5.68
Genipin-1-β-gentiobioside	31	92.76 ± 5.85	87.69 ± 1.34	92.05 ± 5.30	96.27 ± 4.76
	1248	93.24 ± 4.68	96.54 ± 3.95	90.51 ± 5.12	94.81 ± 7.35
	19962	100.83 ± 6.76	97.90 ± 7.67	98.10 ± 6.62	99.08 ± 9.76
Secoxyloganin	32	93.62 ± 3.57	92.98 ± 5.47	93.90 ± 4.76	92.39 ± 3.20
	1288	91.57 ± 4.35	94.47 ± 4.03	90.46 ± 4.78	96.68 ± 4.75
	20602	98.82 ± 4.92	101.32 ± 6.26	98.30 ± 6.69	95.82 ± 7.45
Neochlorogenic acid	31	94.30 ± 3.49	96.81 ± 4.27	93.31 ± 4.71	94.07 ± 3.66
	1260	95.90 ± 4.45	89.67 ± 2.12	92.58 ± 4.53	96.86 ± 3.03
	20152	88.15 ± 1.30	98.42 ± 8.36	88.22 ± 1.64	102.90 ± 5.17
Chlorogenic acid	38	92.50 ± 4.98	91.84 ± 4.02	94.70 ± 3.89	94.88 ± 4.33
	1500	93.12 ± 4.73	93.88 ± 7.12	90.85 ± 3.64	91.36 ± 5.08
	24000	87.96 ± 1.45	88.84 ± 2.13	90.49 ± 1.56	89.06 ± 1.73
Cryptochlorogenic acid	27	92.77 ± 4.18	93.64 ± 4.54	92.07 ± 3.53	93.42 ± 2.51
	1088	94.93 ± 3.86	94.95 ± 6.15	95.98 ± 4.68	95.95 ± 4.95
	17402	88.24 ± 1.79	90.04 ± 2.29	90.61 ± 1.16	90.32 ± 1.08
Cefuroxime	696.25	97.92 ± 3.89	93.58 ± 3.69	93.68 ± 4.78	96.73 ± 3.95
	27850	95.09 ± 5.07	97.51 ± 3.49	93.01 ± 6.87	89.93 ± 2.56
	445600	100.78 ± 8.87	101.16 ± 9.03	89.62 ± 1.44	100.74 ± 13.72