Determination of Anlotinib, a Tyrosine Kinase Inhibitor, in Rat Plasma by UHPLC-MS/MS and Its Application to a Pharmacokinetic Study

<table class="table-group" id="tab5"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td class="align_left">Parameters</td><td class="align_center">Mean ± SD</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td class="align_left">AUC<sub>0-<i>t</i></sub> (ng/mL·h)</td><td class="align_center">184.431 ± 49.827</td></tr><tr><td class="align_left">AUC<sub>0-∞</sub> (ng/mL·h)</td><td class="align_center">185.594 ± 49.234</td></tr><tr><td class="align_left">MRT<sub>(0-<i>t</i>)</sub> (h)</td><td class="align_center">8.982 ± 1.452</td></tr><tr><td class="align_left">MRT<sub>(0-∞)</sub> (h)</td><td class="align_center">9.199 ± 1.214</td></tr><tr><td class="align_left"><i>t </i><sub>1/2</sub><i> z</i> (h)</td><td class="align_center">5.05 ± 0.62</td></tr><tr><td class="align_left"><i>T </i><sub>max</sub> (h)</td><td class="align_center">3.333 ± 0.816</td></tr><tr><td class="align_left"><i>C </i><sub>max</sub> (ng/mL)</td><td class="align_center">24.219 ± 4.311</td></tr><tr><td class="align_left">CL/F (L/h/kg)</td><td class="align_center">56.512 ± 12.228</td></tr><tr><td class="align_left">V/F (L/kg)</td><td class="align_center">406.029 ± 72.748</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Pharmacokinetic parameters of anlotinib in plasma following an oral administration at a dose of 10 mg/kg in rats (<i>n</i> = 6).</div>

Journal of Analytical Methods in Chemistry

tab5

Table 5

Table 5: Determination of Anlotinib, a Tyrosine Kinase Inhibitor, in Rat Plasma by UHPLC-MS/MS and Its Application to a Pharmacokinetic Study 