Research Article
Determination of Anlotinib, a Tyrosine Kinase Inhibitor, in Rat Plasma by UHPLC-MS/MS and Its Application to a Pharmacokinetic Study
Table 5
Pharmacokinetic parameters of anlotinib in plasma following an oral administration at a dose of 10 mg/kg in rats (n = 6).
| Parameters | Mean ± SD |
| AUC0-t (ng/mL·h) | 184.431 ± 49.827 | AUC0-∞ (ng/mL·h) | 185.594 ± 49.234 | MRT(0-t) (h) | 8.982 ± 1.452 | MRT(0-∞) (h) | 9.199 ± 1.214 | t 1/2 z (h) | 5.05 ± 0.62 | T max (h) | 3.333 ± 0.816 | C max (ng/mL) | 24.219 ± 4.311 | CL/F (L/h/kg) | 56.512 ± 12.228 | V/F (L/kg) | 406.029 ± 72.748 |
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