Determination of Anlotinib, a Tyrosine Kinase Inhibitor, in Rat Plasma by UHPLC-MS/MS and Its Application to a Pharmacokinetic Study

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td class="align_left">Drugs</td><td class="align_center">Precursor ion</td><td class="align_center">Product ion</td><td class="align_center">Fragmentor (V)</td><td class="align_center">Collision energy (eV)</td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td class="align_left">Anlotinib</td><td class="align_center">408.2</td><td class="align_center">339.1</td><td class="align_center">132</td><td class="align_center">18</td></tr><tr><td class="align_left">Imatinib</td><td class="align_center">494.3</td><td class="align_center">394.1</td><td class="align_center">170</td><td class="align_center">29</td></tr><tr class="table-tr"><td colspan="5"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>MS parameters for anlotinib and imatinib (IS).</div>

Journal of Analytical Methods in Chemistry

tab1

Table 1

Table 1: Determination of Anlotinib, a Tyrosine Kinase Inhibitor, in Rat Plasma by UHPLC-MS/MS and Its Application to a Pharmacokinetic Study 