Determination of Anlotinib, a Tyrosine Kinase Inhibitor, in Rat Plasma by UHPLC-MS/MS and Its Application to a Pharmacokinetic Study

Figure 2

Representative MRM chromatograms of anlotinib and imatinib (IS) in rat plasma. (a) Blank samples from plasma (A); (b) sample at 40 ng/mL for anlotinib in plasma; (c) sample at 10 min after oral administration of 10 mg/kg anlotinib to rat.

(a)

(b)

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