Development and Validation of Discriminative Dissolution Method for Metformin Immediate-Release Film-Coated Tablets

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td class="align_left"> </td><td class="align_center">pH 1.2 (HCl and NaCl)</td><td class="align_center">Acetate buffer pH 4.5</td><td class="align_center">Phosphate buffer pH 6.8</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td class="align_left">Solubility of metformin HCL (<i>n</i> = 2)</td><td class="align_center">144.16 mg/mL</td><td class="align_center">165.96 mg/mL</td><td class="align_center">170.58 mg/mL</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><div>Calculated from 1000 mg/250 mL × 3 = 12 mg/mL.<br/></div></td></tr></table>

<div>Results from the solubility test of metformin HCL in the proposed dissolution media.</div>

Journal of Analytical Methods in Chemistry

tab1

Table 1

Table 1: Development and Validation of Discriminative Dissolution Method for Metformin Immediate-Release Film-Coated Tablets 