Research Article

A Pyridazine-Based Fluorescent Probe Targeting Aβ Plaques in Alzheimer’s Disease

Table 1

Fluorescence profile and KD and log P values of probe 3 with Aβ aggregates.

Optical propertiesProbe 3

λex (nm)408
λem (nm)670
λex/λem with Aβ (nm)408/604
Fold increase with Aβ34.92
KD (mean ± SD) (µM)0.35 ± 0.03
log P (lipophilicity)2.94