Rapid Identification of the Multiple Absorbed Bioactive Components and Metabolites in Rat Serum after Oral Administration of Wu-Jia Sheng-Hua Capsule by UPLC-ESI-MS

<table class="table-group" id="tab3"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td align="left">Peak no.</td><td align="center">Rt (min.) <br/>extract/plasma</td><td align="center">Positive ions (<i>m/z</i>)</td><td align="left">Origin</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td align="left">M1</td><td align="center">4.78/4.79</td><td align="center">207, 229</td><td align="left"><i>Radix Angelicae Sinensis</i>  <br/><i>Rhizoma  </i><i>Chuanxiong </i>  <br/><i>Semen Persicae  </i></td></tr><tr><td align="left">M2</td><td align="center">5.12/5.14</td><td align="center">262, 244</td><td align="left"><i>Radix </i>et<i> Caulis Acanthopanacis Santicosi  </i></td></tr><tr><td align="left">M3</td><td align="center">6.94/6.92</td><td align="center">189, 154</td><td align="left"><i>Radix Angelicae Sinensis</i>  <br/><i>Rhizoma  </i><i>Chuanxiong </i>  <br/><i>Semen Persicae  </i></td></tr><tr><td align="left">M4</td><td align="center">7.59/7.61</td><td align="center">323, 245, 308</td><td align="left"><i>Rhizoma Zingiberis Preparata </i></td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

The retention times, +ESI-MS/MS data (<svg height="14.85" id="M5" style="vertical-align:-2.22495pt" version="1.1" viewbox="0 0 29 14.85" width="29" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,12.012)"><path d="M766 88q-40 -45 -83.5 -72.5t-63.5 -27.5q-39 0 -16 103l49 224q15 68 -10 68q-36 0 -112.5 -78.5t-105.5 -133.5q-27 -101 -38 -165q-35 -4 -77 -18l-6 6q42 153 70 288q12 55 10 78t-19 23q-38 0 -114 -80.5t-101 -131.5q-24 -68 -41 -165q-36 -3 -76 -18l-8 6
q56 202 87 347q7 33 -3 33q-8 0 -31.5 -17.5t-41.5 -35.5l-12 28q42 45 84 72t63 27q44 0 10 -124l-20 -75h2q92 121 193 178q36 21 64 21q62 0 28 -159l-8 -37h2q50 67 103.5 112t94.5 65q39 19 62 19q60 0 23 -156l-45 -189q-9 -39 2 -39q17 0 71 49z" id="x1D45A"></path></g><g transform="matrix(.017,-0,0,-.017,13.475,12.012)"><path d="M368 703l-264 -866h-60l265 866h59z" id="x2F"></path></g><g transform="matrix(.017,-0,0,-.017,20.478,12.012)"><path d="M475 445l-64 -69q-119 -128 -289 -280q27 6 81 -15q66 -26 102 -26q48 0 111 93l23 -19q-41 -84 -75.5 -116.5t-73.5 -32.5q-37 0 -147 53q-43 21 -63 7q-22 -15 -38 -41q-4 -7 -11 -7q-8 10 -8 26q0 38 47 83l292 273q-32 -5 -67 -1q-63 7 -105 7q-32 0 -53.5 -22
t-47.5 -67l-25 13q15 39 38 78q40 66 83 66q57 0 120 -12q52 -10 80 -10q29 0 67 42z" id="x1D467"></path></g>
</svg>), and origins of the metabolites in rat serum after oral administration of WJSH capsule.

Journal of Analytical Methods in Chemistry

tab3

Table 3

Table 3: Rapid Identification of the Multiple Absorbed Bioactive Components and Metabolites in Rat Serum after Oral Administration of Wu-Jia Sheng-Hua Capsule by UPLC-ESI-MS 

Table 3 | Rapid Identification of the Multiple Absorbed Bioactive Components and Metabolites in Rat Serum after Oral Administration of Wu-Jia Sheng-Hua Capsule by UPLC-ESI-MS 