Research Article
Thermoanalytical Investigation of Some Sulfone-Containing Drugs
Table 1
Thermal decomposition data of TGA, DTG, and DTA curves of Dapsone, dimethyl sulfone, and Topiramate.
| Drugs | TGA and DTG | DTA | 1st reaction temperature | 2nd reaction temperature | Endothermic peaks (°C) | Exothermic peaks (°C) | Onset | End set | %wt loss | Onset | End set | %wt loss |
| Dapsone | 339 | 393.41 | 52.174 | 393.41 | 726 | 47.91 | 185.12 (refer to mp), 368.83, 639.34 | 686.34 | Dimethyl sulfone | 170 | 299.13 | 94.53 | 299.13 | 355 | 5.71 | 108.81 (refer to mp), 215.9 | 852.23 | Topiramate | 151 | 393.46 | 73.19 | 393.4 | 722.43 | 25.26 | 130.53 (refer to mp), 154.07 | 181.07, 350.80 |
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