Suboxone Treatment and Recovery Trial (STAR-T): Study Protocol for a Randomised Controlled Trial of Opioid Medication Assisted Treatment with Adjunctive Medication Management Using Therapeutic Drug Monitoring and Contingency Management

Table 3

Interventions under study groups (TDM; TAU).

Intervention	Randomisation Group
	TDM	TAU
Induction	Yes	Yes
Stabilisation	Yes	Yes
Baseline assessments	Yes	Yes
Estimating BUP Elimination Rate	Yes	Yes
Medication education	Yes	Yes
Emergency card	Yes	Yes
Outpatient DOT	Yes	No
Outpatient medication management manualised intervention	Yes	No
UDS at outpatient care	Yes	Yes
Providing prescription take-home doses	Contingent on; UDS & TDM (i.e., abstinence & adherence)	Contingent on; UDS only
Stepped BUP/NX-F take-home doses	Yes	No
Maximum take BUP/NX-F home doses	4 weeks	2 weeks
TDM	Yes	No
Periodic study assessments	Yes	Yes
End of study assessments	Yes	Yes
Psychosocial support	Yes	Yes

BUP: buprenorphine; DOT: directly observed treatment; UDS: urinary drug screen; TDM: therapeutic drug monitoring.