Review Article
Serpin Inhibition Mechanism: A Delicate Balance between Native Metastable State and Polymerization
Table 1
Represents the Scissile bond in various serpins and their protease targets. Antithrombin is an efficient inhibitor of factor Xa, thrombin and factor IXa. Residues flanking the P1-P1′ are also critical for protease multispecificity.