Allergies have increased dramatically in prevalence and severity over the past two decades. It was reported that adaptive immunity plays a critical role in the pathogenesis of this disease. Nevertheless, the implication of innate immune response and the interaction between cells from innate and adaptive immunity, that will finally determine the severity of the allergic process, remain poorly understood. In addition, there is compelling evidence that epithelial cells could license innate and adaptive immune responses at mucosal sites. The presence of distinct immune cell types conjointly to the local production of a triad of cytokines as TSLP (thymic stromal lymphopoietin), IL-13, IL-17, IL-22, IL-23, and IL-33 highlights the complexity of the allergic responses. Consequently, we invite authors to submit original research and review articles that seek to understand the crosstalk between innate and adaptive immune responses in allergic process. We are interested in articles that explore these mechanisms in humans and animal models. Potential topics include, but are not limited to:

• Role of recently described innate cells as nuocytes and innate lymphoid cells on the development of allergic responses
• Getting insight into the crosstalk between dendritic cells, basophils, mast cells, neutrophils, eosinophils, Natural Killer T cells, and conventional T and B lymphocytes on the immunological mechanisms resulting in allergy
• Elucidating the impact of epithelial cell dysfunction on both innate and adaptive immunity in allergy
• New hypothesis to explain the development of allergic process observed in allergic asthma, contact, and food allergy taking in consideration epithelial cells, immune cells, and microbial antigens
• Determining the implication of innate cells on the induction of allergen immunotherapy
• Development of new immunotherapeutic strategies to treat seasonal or chronic allergy

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