Twin Studies of Atopic Dermatitis: Interpretations and Applications in the Filaggrin Era

Table 1

Population-based twin studies of the concordance and heritability of atopic dermatitis.

Study	Country	Age; (years)	(pairs)	MZ rate	DZ rate	MZ/DZ; ratio	Heritability; (%)	Diagnostic; method
Edfors-Lubs (1971) [7]	Sweden	42–81	6996	0.154	0.045	3.42		Self-report
Schultz Larsen et al. (1986) [8]	Denmark	7–21	592	0.86	0.21	4.1		Clinical examination
Larsen (1993) [9]	Denmark	8–22	812	0.72	0.23	3.13		Clinical examination
Lichtenstein and Svartengren (1997) [10]	Sweden	7–9	1339					Parent-report
Boys				0.54	0.35	1.54	74
Girls				0.73	0.40	1.83	71
Strachan et al. (2001) [11]	UK	18–72	873					Clinical examination
<50				0.51	0.34	1.50
>50				0.47	0.09	5.22
Nystad et al. (2005) [12]	Norway	18–35	3334				69	Self-report
Boys				0.43	0.06	7.17
Girls				0.44	0.10	4.40
Thomsen et al. (2007) [13]	Denmark	12–41	11515	0.57	0.21	2.71		Self-report
Boys							82
Girls							80
Jäderberg et al. (2012) [14]	Denmark	3–20	9694					Self-report/parent-report
Assisted reproduction							86
Spontaneous conception							78

MZ, monozygotic; DZ, dizygotic.